a Record control number 000321585500007

a ISSN 0954-6634

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number WR140

b Item number .E34 2013

a Personal name Kaptanoglu, Asli Feride.

h Medium Electronic Document

a Title Effect of isotretinoin on prothrombin time (PT), international normalized ratio (INR), and activated partial thromboplastin time (aPTT)

c Statement of responsibility, etc Aslı Feride Kaptanoglu, Murat Uncu, Selçuk Özyurt, Evren Hıncal.

b Name of publisher, distributor, etc Informa Healthcare,

c Date of publication, distribution, etc 2013.

a Summary, etc Patients with severe acne may need elective/urgent surgical interventions during treatment with isotretinoin and it is critical for the surgeon to consider the possible effects of this medication on coagulation systems. The aim of this study is to determine the changes in prothrombin time (PT), international normalized ratio (INR), and activated partial thromboplastin time (aPTT) during isotretinoin treatment. PT, aPTT, and INR values of 51 severe acne patients were evaluated during routine pretreatment biochemical analysis. Only patients with normal values were included in the study. The results of before and after 1 month treatment were compared statistically. There were no statistically significant change in mean alanine aminotranferease (ALT), aspartate aminotransferase (AST), PT, and INR values after treatment. A significant increase in aPTT was detected. The INR values, which are more trusted and safe, showed no difference. Isotretinoin seems to have no effect on these coagulation parameters.

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Topical term or geographic name as entry element Dermatology

a Topical term or geographic name as entry element Isotretinoin

a Topical term or geographic name as entry element side effects

a Topical term or geographic name as entry element prothrombin time

a Topical term or geographic name as entry element activated partial thromboplastin time

a Topical term or geographic name as entry element Routıne Blood-Tests

a Topical term or geographic name as entry element Thrombocytopenıa;

a Topical term or geographic name as entry element Fibrinolysis

g Relationship information Aug 2013, Vol.24, Issue:4, p.272-274

t Title Journal Of Dermatologıcal Treatment

x International Standard Serial Number 09546634

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.3109/09546634.2011.652063